1. How do you update the prices on a larger order or quote? This can be a problem when the quote is older and the customer would like to have it current.
2. or How can I apply quantity price levels if items are on several different lines?

Click on the Update Prices button at the top of the screen.

This button saves the manual refreshing of each individual line item. It also evaluates the sum quantity for each item and applies appropriate price levels based on customer and item settings.